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Exosomal transfer of proteins and RNAs at synapses in the nervous system

Overview of attention for article published in Biology Direct, November 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
2 X users

Citations

dimensions_citation
213 Dimensions

Readers on

mendeley
287 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
Title
Exosomal transfer of proteins and RNAs at synapses in the nervous system
Published in
Biology Direct, November 2007
DOI 10.1186/1745-6150-2-35
Pubmed ID
Authors

Neil R Smalheiser

Abstract

Many cell types have been reported to secrete small vesicles called exosomes, that are derived from multivesicular bodies and that can also form from endocytic-like lipid raft domains of the plasma membrane. Secretory exosomes contain a characteristic composition of proteins, and a recent report indicates that mast cell exosomes harbor a variety of mRNAs and microRNAs as well. Exosomes express cell recognition molecules on their surface that facilitate their selective targeting and uptake into recipient cells. In this review, I suggest that exosomal secretion of proteins and RNAs may be a fundamental mode of communication within the nervous system, supplementing the known mechanisms of anterograde and retrograde signaling across synapses. In one specific scenario, exosomes are proposed to bud from the lipid raft region of the postsynaptic membrane adjacent to the postsynaptic density, in a manner that is stimulated by stimuli that elicit long-term potentiation. The exosomes would then transfer newly synthesized synaptic proteins (such as CAM kinase II alpha) and synaptic RNAs to the presynaptic terminal, where they would contribute to synaptic plasticity. The model is consistent with the known cellular and molecular features of synaptic neurobiology and makes a number of predictions that can be tested in vitro and in vivo.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 287 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Germany 2 <1%
Japan 2 <1%
Chile 1 <1%
United Kingdom 1 <1%
Korea, Republic of 1 <1%
Brazil 1 <1%
Spain 1 <1%
Unknown 275 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 78 27%
Student > Ph. D. Student 58 20%
Student > Bachelor 33 11%
Student > Master 23 8%
Professor 17 6%
Other 54 19%
Unknown 24 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 125 44%
Biochemistry, Genetics and Molecular Biology 34 12%
Medicine and Dentistry 32 11%
Neuroscience 26 9%
Engineering 8 3%
Other 30 10%
Unknown 32 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2021.
All research outputs
#4,218,790
of 25,374,647 outputs
Outputs from Biology Direct
#157
of 537 outputs
Outputs of similar age
#18,233
of 166,619 outputs
Outputs of similar age from Biology Direct
#3
of 6 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,619 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.