Title |
Physiological and neurophysiological determinants of postcancer fatigue: design of a randomized controlled trial
|
---|---|
Published in |
BMC Cancer, June 2012
|
DOI | 10.1186/1471-2407-12-256 |
Pubmed ID | |
Authors |
Hetty Prinsen, Gijs Bleijenberg, Machiel J Zwarts, Maria T E Hopman, Arend Heerschap, Hanneke W M van Laarhoven |
Abstract |
Postcancer fatigue is a frequently occurring, severe, and invalidating problem, impairing quality of life. Although it is possible to effectively treat postcancer fatigue with cognitive behaviour therapy, the nature of the underlying (neuro)physiology of postcancer fatigue remains unclear. Physiological aspects of fatigue include peripheral fatigue, originating in muscle or the neuromuscular junction; central fatigue, originating in nerves, spinal cord, and brain; and physical deconditioning, resulting from a decreased cardiopulmonary function. Studies on physiological aspects of postcancer fatigue mainly concentrate on deconditioning. Peripheral and central fatigue and brain morphology and function have been studied for patients with fatigue in the context of chronic fatigue syndrome and neuromuscular diseases and show several characteristic differences with healthy controls. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 3 | 3% |
Unknown | 109 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 17% |
Student > Ph. D. Student | 15 | 13% |
Researcher | 14 | 13% |
Student > Bachelor | 9 | 8% |
Librarian | 6 | 5% |
Other | 20 | 18% |
Unknown | 29 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 21% |
Psychology | 16 | 14% |
Sports and Recreations | 12 | 11% |
Nursing and Health Professions | 8 | 7% |
Agricultural and Biological Sciences | 6 | 5% |
Other | 13 | 12% |
Unknown | 33 | 29% |