Title |
Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels
|
---|---|
Published in |
BMC Infectious Diseases, June 2016
|
DOI | 10.1186/s12879-016-1628-6 |
Pubmed ID | |
Authors |
Erik Sörstedt, Staffan Nilsson, Anders Blaxhult, Magnus Gisslén, Leo Flamholc, Anders Sönnerborg, Aylin Yilmaz |
Abstract |
Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. HIV-1-infected ART naïve adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Viral blips were found in 76/735 included subjects (10.3 %) and in 90/4449 samples (2.0 %). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170 weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log10 4.85 copies/mL) compared with subjects without blips (median log10 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). The Swedish national HIV-cohort has a low incidence of viral blips (10 %). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 2 | 17% |
United States | 2 | 17% |
Philippines | 1 | 8% |
Ecuador | 1 | 8% |
Unknown | 6 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 81 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 21 | 26% |
Researcher | 13 | 16% |
Student > Ph. D. Student | 9 | 11% |
Student > Postgraduate | 7 | 9% |
Student > Bachelor | 4 | 5% |
Other | 14 | 17% |
Unknown | 13 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 38% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Immunology and Microbiology | 7 | 9% |
Nursing and Health Professions | 5 | 6% |
Agricultural and Biological Sciences | 5 | 6% |
Other | 9 | 11% |
Unknown | 17 | 21% |