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Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels

Overview of attention for article published in BMC Infectious Diseases, June 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

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11 tweeters

Citations

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12 Dimensions

Readers on

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35 Mendeley
Title
Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels
Published in
BMC Infectious Diseases, June 2016
DOI 10.1186/s12879-016-1628-6
Pubmed ID
Authors

Erik Sörstedt, Staffan Nilsson, Anders Blaxhult, Magnus Gisslén, Leo Flamholc, Anders Sönnerborg, Aylin Yilmaz

Abstract

Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. HIV-1-infected ART naïve adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Viral blips were found in 76/735 included subjects (10.3 %) and in 90/4449 samples (2.0 %). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170 weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log10 4.85 copies/mL) compared with subjects without blips (median log10 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). The Swedish national HIV-cohort has a low incidence of viral blips (10 %). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 40%
Researcher 7 20%
Student > Postgraduate 3 9%
Student > Ph. D. Student 2 6%
Student > Bachelor 2 6%
Other 4 11%
Unknown 3 9%
Readers by discipline Count As %
Medicine and Dentistry 16 46%
Immunology and Microbiology 4 11%
Agricultural and Biological Sciences 3 9%
Biochemistry, Genetics and Molecular Biology 3 9%
Nursing and Health Professions 2 6%
Other 4 11%
Unknown 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#2,313,451
of 11,220,852 outputs
Outputs from BMC Infectious Diseases
#711
of 4,201 outputs
Outputs of similar age
#65,436
of 269,395 outputs
Outputs of similar age from BMC Infectious Diseases
#29
of 189 outputs
Altmetric has tracked 11,220,852 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,201 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,395 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 189 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.