| Title |
Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels
|
|---|---|
| Published in |
BMC Infectious Diseases, June 2016
|
| DOI | 10.1186/s12879-016-1628-6 |
| Pubmed ID | |
| Authors |
Erik Sörstedt, Staffan Nilsson, Anders Blaxhult, Magnus Gisslén, Leo Flamholc, Anders Sönnerborg, Aylin Yilmaz |
| Abstract |
Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. HIV-1-infected ART naïve adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Viral blips were found in 76/735 included subjects (10.3 %) and in 90/4449 samples (2.0 %). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170 weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log10 4.85 copies/mL) compared with subjects without blips (median log10 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). The Swedish national HIV-cohort has a low incidence of viral blips (10 %). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 2 | 17% |
| United States | 2 | 17% |
| Philippines | 1 | 8% |
| Ecuador | 1 | 8% |
| Unknown | 6 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 81 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 21 | 26% |
| Researcher | 13 | 16% |
| Student > Ph. D. Student | 9 | 11% |
| Student > Postgraduate | 7 | 9% |
| Student > Bachelor | 4 | 5% |
| Other | 14 | 17% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 38% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Immunology and Microbiology | 7 | 9% |
| Nursing and Health Professions | 5 | 6% |
| Agricultural and Biological Sciences | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 17 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2021.
All research outputs
#5,164,393
of 25,398,331 outputs
Outputs from BMC Infectious Diseases
#1,784
of 8,609 outputs
Outputs of similar age
#85,766
of 369,189 outputs
Outputs of similar age from BMC Infectious Diseases
#31
of 171 outputs
Altmetric has tracked 25,398,331 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,609 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,189 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.