| Title |
A tissue biopsy-based epigenetic multiplex PCR assay for prostate cancer detection
|
|---|---|
| Published in |
BMC Urology, June 2012
|
| DOI | 10.1186/1471-2490-12-16 |
| Pubmed ID | |
| Authors |
Leander Van Neste, Joseph Bigley, Adam Toll, Gaëtan Otto, James Clark, Paul Delrée, Wim Van Criekinge, Jonathan I Epstein |
| Abstract |
PSA-directed prostate cancer screening leads to a high rate of false positive identifications and an unnecessary biopsy burden. Epigenetic biomarkers have proven useful, exhibiting frequent and abundant inactivation of tumor suppressor genes through such mechanisms. An epigenetic, multiplex PCR test for prostate cancer diagnosis could provide physicians with better tools to help their patients. Biomarkers like GSTP1, APC and RASSF1 have demonstrated involvement with prostate cancer, with the latter two genes playing prominent roles in the field effect. The epigenetic states of these genes can be used to assess the likelihood of cancer presence or absence. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| United Kingdom | 1 | 2% |
| Hong Kong | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 51 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 20% |
| Student > Bachelor | 8 | 14% |
| Student > Master | 7 | 13% |
| Student > Ph. D. Student | 7 | 13% |
| Other | 4 | 7% |
| Other | 9 | 16% |
| Unknown | 10 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 23% |
| Medicine and Dentistry | 12 | 21% |
| Biochemistry, Genetics and Molecular Biology | 11 | 20% |
| Engineering | 4 | 7% |
| Computer Science | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 14 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2012.
All research outputs
#17,664,478
of 22,675,759 outputs
Outputs from BMC Urology
#484
of 741 outputs
Outputs of similar age
#124,052
of 166,909 outputs
Outputs of similar age from BMC Urology
#4
of 5 outputs
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