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Effect of β-sitosterol against methyl nitrosourea-induced mammary gland carcinoma in albino rats

Overview of attention for article published in BMC Complementary and Alternative Medicine, July 2016
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Title
Effect of β-sitosterol against methyl nitrosourea-induced mammary gland carcinoma in albino rats
Published in
BMC Complementary and Alternative Medicine, July 2016
DOI 10.1186/s12906-016-1243-5
Pubmed ID
Authors

Chetan Manral, Subhadeep Roy, Manjari Singh, Swetlana Gautam, Rajnish K. Yadav, Jitendra K Rawat, Uma Devi, Md Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas

Abstract

The present study was in quested to study the effects of β-sitosterol on methyl nitrosourea (MNU) induced mammary gland carcinoma in albino wistar rats. Animals were randomized and divided into four groups of eight animals each. Group I (sham control 1 % CMC in normal saline p.o.); Group II (toxic control, MNU 47 mg/kg, i.v); Group III (MNU 47 mg/kg, i.v + β-sitosterol, 10 mg/kg, p.o); Group IV (MNU 47 mg/kg, i.v + β-sitosterol, 20 mg/kg, p.o). Toxicity was induced by single i.v. injection of MNU followed by β-sitosterol supplementation therapy for 115 days at the dose mentioned above. Treatment with β-sitosterol evidenced decrease in the alveolar bud and lobule score in the whole mount of the mammary gland. β-sitosterol exhibited diminishing effect on oxidative stress through synchronizing lipid and enzymatic antioxidant defense. A significant decrease in the saturated and unsaturated fatty acid was evident with the MNU treatment and β-sitosterol demonstrated a marked effect on it. Pgp 9.5 expression was dose dependently upregulated by β-sitosterol treatment in comparison to MNU treatment. On the contrary, downregulated NF-kB expression was perceived, when β-sitosterol was concomitantly administered with MNU. β-sitosterol afforded significant protection against the deleterious effects of MNU.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 23%
Student > Bachelor 2 15%
Unspecified 2 15%
Student > Master 2 15%
Professor > Associate Professor 2 15%
Other 2 15%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 46%
Unspecified 3 23%
Biochemistry, Genetics and Molecular Biology 2 15%
Agricultural and Biological Sciences 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2016.
All research outputs
#5,914,463
of 8,161,363 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,338
of 2,042 outputs
Outputs of similar age
#167,422
of 257,480 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#47
of 95 outputs
Altmetric has tracked 8,161,363 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,042 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,480 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.