| Title |
Effects of rituximab in two patients with dysferlin-deficient muscular dystrophy
|
|---|---|
| Published in |
BMC Musculoskeletal Disorders, July 2010
|
| DOI | 10.1186/1471-2474-11-157 |
| Pubmed ID | |
| Authors |
Alberto Lerario, Filippo Cogiamanian, Chiara Marchesi, Marzia Belicchi, Nereo Bresolin, Laura Porretti, Yvan Torrente |
| Abstract |
The administration of rituximab (RTX) in vivo results in B-cell depletion, but evidence for multiple mechanisms of action have been reported. Surprisingly, B cell depletion produced a response in patients with polymyositis, which is characterized as a T cell-mediated autoimmune disorder with biopsy findings similar to Miyoshi myopathy (MM). Indeed, in dysferlinopathies, there is evidence of immune system involvement including the presence of muscle inflammation and a down regulation of the complement inhibitory factor, CD55. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 16% |
| Student > Master | 8 | 16% |
| Student > Ph. D. Student | 7 | 14% |
| Student > Bachelor | 6 | 12% |
| Other | 6 | 12% |
| Other | 8 | 16% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 27% |
| Agricultural and Biological Sciences | 13 | 27% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Nursing and Health Professions | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 5 | 10% |
| Unknown | 8 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2022.
All research outputs
#14,111,272
of 23,381,576 outputs
Outputs from BMC Musculoskeletal Disorders
#2,054
of 4,141 outputs
Outputs of similar age
#75,678
of 96,538 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#17
of 29 outputs
Altmetric has tracked 23,381,576 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,141 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,538 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.