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High frequency of pre-existing neutralizing antibody responses in patients with dengue during an outbreak in Central Brazil

Overview of attention for article published in BMC Infectious Diseases, October 2016
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52 Mendeley
Title
High frequency of pre-existing neutralizing antibody responses in patients with dengue during an outbreak in Central Brazil
Published in
BMC Infectious Diseases, October 2016
DOI 10.1186/s12879-016-1867-6
Pubmed ID
Authors

Angela Ferreira Lopes de Teive e Argolo, Valéria Christina de Rezende Féres, Marli Tenório Cordeiro, Lucimeire Antonelli da Silveira, Adriana Oliveira Guilarde, Ernesto Torres de Azevedo Marques, Wayner Vieira de Souza, Celina Maria Turchi Martelli

Abstract

This study aims to identify dengue neutralizing antibody response in patients with dengue from a well-characterized cohort during an outbreak in central Brazil, 2012-2013. We analyzed paired samples from 40 patients with severe dengue and 20 patients with dengue. Eligibility criteria were: IgM, NS1Ag and/or RT-PCR positivity and positive IgG result. Plaque reduction neutralization test (PRNT50) from DENV-1 to DENV-4 was performed to identify serotype-specific NAbs response. An infecting serotype was defined as ≥4-fold increase in DENV NAbs in paired samples. Monotypic response was classified as PRNT50 ≥ 1/20 to only one DENV serotype, and multitypic response was considered to be PRNT50 ≥ 1/20 to two or more serotypes simultaneously. Patients were mainly adults. Virological dengue infection was confirmed by RT-PCR: DENV-4(n = 14) and DENV-1(n = 10). Forty-four out of 60(73.3 %) patients had NAbs to DENV-4, DENV-1(68.3 %), DENV-2(68.3 %) and DENV-3(61.6 %) respectively. Fifteen percent of the cases presented monotypic response, whereas 85 % had multitypic response. DENV-4 infected-patients presented the greatest difference in PRNT50 titers compared with other serotypes. Pre-existing DENV NAbs was not correlated with disease severity. This was the first time that DENV-4 was implicated in an epidemic in the region. Our data indicates high exposure of multiple DENV serotypes in all age groups in the pre-dengue vaccine era and also previous to Zika virus introduction in Brazil.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 51 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 31%
Researcher 14 27%
Other 5 10%
Student > Postgraduate 4 8%
Unspecified 3 6%
Other 10 19%
Readers by discipline Count As %
Medicine and Dentistry 14 27%
Agricultural and Biological Sciences 8 15%
Unspecified 7 13%
Pharmacology, Toxicology and Pharmaceutical Science 7 13%
Biochemistry, Genetics and Molecular Biology 5 10%
Other 11 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2016.
All research outputs
#7,716,889
of 12,341,991 outputs
Outputs from BMC Infectious Diseases
#2,542
of 4,546 outputs
Outputs of similar age
#147,310
of 266,707 outputs
Outputs of similar age from BMC Infectious Diseases
#104
of 189 outputs
Altmetric has tracked 12,341,991 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,546 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 189 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.