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Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae

Overview of attention for article published in BMC Biology, March 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

blogs
1 blog
twitter
13 tweeters

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
72 Mendeley
Title
Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae
Published in
BMC Biology, March 2013
DOI 10.1186/1741-7007-11-24
Pubmed ID
Authors

Michaela de Clare, Stephen G Oliver

Abstract

Copy-number variation (CNV), rather than complete loss of gene function, is increasingly implicated in human disease. Moreover, gene dosage is recognised as important in tumourigenesis, and there is an increasing realisation that CNVs may not be just symptomatic of the cancerous state but may, in fact, be causative. However, the identification of CNV-related phenotypes for mammalian genes is a slow process, due to the technical difficulty of constructing deletion mutants. Using the genome-wide deletion library for the model eukaryote, Saccharomyces cerevisiae, we have identified genes (termed haploproficient, HP) which, when one copy is deleted from a diploid cell, result in an increased rate of proliferation. Since haploproficiency under nutrient-sufficient conditions is a novel phenotype, we sought here to characterise a subset of the yeast haploproficient genes which seem particularly relevant to human cancers.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
Netherlands 1 1%
Canada 1 1%
Singapore 1 1%
Unknown 67 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 33%
Researcher 15 21%
Student > Bachelor 7 10%
Student > Master 7 10%
Student > Doctoral Student 4 6%
Other 15 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 65%
Biochemistry, Genetics and Molecular Biology 14 19%
Medicine and Dentistry 3 4%
Unspecified 3 4%
Immunology and Microbiology 1 1%
Other 4 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2013.
All research outputs
#1,107,110
of 13,526,911 outputs
Outputs from BMC Biology
#372
of 1,189 outputs
Outputs of similar age
#13,353
of 147,484 outputs
Outputs of similar age from BMC Biology
#1
of 1 outputs
Altmetric has tracked 13,526,911 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,189 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 147,484 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them