Title |
The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post- 2004
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Published in |
BMC Infectious Diseases, October 2016
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DOI | 10.1186/s12879-016-1928-x |
Pubmed ID | |
Authors |
Hanping Li, Shuai Chang, Yang Han, Daomin Zhuang, Lin Li, Yongjian Liu, Siyang Liu, Zuoyi Bao, Wenfu Zhang, Hongbin Song, Taisheng Li, Jingyun Li |
Abstract |
The widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic. We conducted an epidemiological study enrolling treatment-naïve HIV-1-positive subjects at the Peking Union Medical College Hospital since 1991. Drug resistance was determined by submitting the sequences to the Stanford University Network HIV-1 database. Of 521 participants, 478 samples were amplified and sequenced successfully. HIV Transmitted drug resistance prevalence in China was determined to be 6.7 %. We did not find significant differences in the TDR rate by demographic characteristics. No significant time trend in the prevalence of overall TDR was observed (p > 0.05). We identified an intermediate prevalence of transmitted drug resistance (TDR), exhibiting a stable time trend. These findings enhance our understanding of HIV-1 drug resistance prevalence and time trend, and provide some guidelines for the comprehensive public health strategy of TDR prevention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 25% |
Canada | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 22% |
Other | 5 | 16% |
Researcher | 4 | 13% |
Student > Ph. D. Student | 2 | 6% |
Student > Doctoral Student | 1 | 3% |
Other | 3 | 9% |
Unknown | 10 | 31% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Social Sciences | 2 | 6% |
Psychology | 2 | 6% |
Other | 5 | 16% |
Unknown | 12 | 38% |