Data on fecal vanc concentration https://t.co/n9AHo9uN5O Recent data also shows no difference in clinical outcome between 125 mg vs 500 mg https://t.co/e8OxEFlkt5
RT @DrToddLee: @ABsteward The PK says to me --- maybe 1-2 days max higher dose in severe disease and then resume 125 qid. Love this sherbro…
@DrToddLee @mykkymcg @AntibioticDoc @IdVilchez @dralicehan @MIDCUSA @wfwrighID Absolutely! We discussed this a few weeks ago here: https://t.co/X3umsh71G1
RT @DrToddLee: @MIDCUSA @AntibioticDoc Believe it. Also the MIC for "R" needs to be adjusted in the stool where drug levels can exceed 20…
@MIDCUSA @AntibioticDoc Believe it. Also the MIC for "R" needs to be adjusted in the stool where drug levels can exceed 2000mg/L https://t.co/kVRfQ6AmUg
RT @DrDidwania_ID: @JamesWilsonDO1 @IdVilchez @BradSpellberg @DrToddLee @Gnfidz @RushCCH_ID @PaulSaxMD PO vancomycin is great because it’s…
@JamesWilsonDO1 @IdVilchez @BradSpellberg @DrToddLee @Gnfidz @RushCCH_ID @PaulSaxMD PO vancomycin is great because it’s extremely dose adjustable depending on severity of disease and frequency of stools. Some concern for resistance but low likelihood. Even
RT @MIDCUSA: Fecal pharmokinetics of orally administered vancomycin in patients with C. diff shows concentrations of 400 mcg/g stool. At MI…
RT @MIDCUSA: Fecal pharmokinetics of orally administered vancomycin in patients with C. diff shows concentrations of 400 mcg/g stool. At MI…
RT @MIDCUSA: Fecal pharmokinetics of orally administered vancomycin in patients with C. diff shows concentrations of 400 mcg/g stool. At MI…
Fecal pharmokinetics of orally administered vancomycin in patients with C. diff shows concentrations of 400 mcg/g stool. At MIC of 32 mcg it is equal to 125x MIC. https://t.co/BZXEL2O7Az #IDTwitter #TwitteRx #cdiff https://t.co/ktJyG2wJGQ
RT @didwania1: Fecal pharmokinetics of orally administered vancomycin in patients with C. diff shows concentrations of 400 mcg/g stool. At…
@wfwrighID Efficacy dependent on stool frequency which effects oral vancomycin concentration. Nice article discussing this: https://t.co/73FECpdKhL https://t.co/kDY3Ehsu8R https://t.co/coEBRCKtVa
RT @didwania1: Fecal pharmokinetics of orally administered vancomycin in patients with C. diff shows concentrations of 400 mcg/g stool. At…
Fecal pharmokinetics of orally administered vancomycin in patients with C. diff shows concentrations of 400 mcg/g stool. At MIC of 32 mcg it is equal to 125x MIC. https://t.co/73FECpvl9j #ECCMID2022 #IDTwitter #TwitteRx
@jessecouk https://t.co/itD6WdPxuH I agree 100% as demonstrated in this paper, might be ok to increase dosage for a short period in patients with severe diarrhea
@a_lepak @IdVilchez @JVG_GIMD @wfwrighID @BradSpellberg @ABsteward @SAIRABT @AntibioticDoc @Boghuma @boulware_dr @sigal_md @ClancyNeil In more significant disease I start up front with 500 or 250 and go to 125 in a few days. https://t.co/kVRfQ6AmUg
@SAIRABT @IDSAInfo Levels achieved in stool exceed 2000. https://t.co/kVRfQ6AmUg
RT @DrToddLee: @ABsteward The PK says to me --- maybe 1-2 days max higher dose in severe disease and then resume 125 qid. Love this sherbro…
@ABsteward The PK says to me --- maybe 1-2 days max higher dose in severe disease and then resume 125 qid. Love this sherbrooke study #quebec https://t.co/kVRfQ6AmUg
Why does IDSA say to increase vanc dose to 500 mg QID for severe/fulminant C diff? Answer: "Despite the lack of data, it seems prudent" 1,2. https://t.co/PyaVo9kRQc 3. https://t.co/4zmMc9Aiyo 4. https://t.co/V6rZOidyYx https://t.co/wyMSalpf8a
@padstamundo Do clostridium in stool need different breakpoints to vancomycin? Even 4-16mg/L seems easily surmountable https://t.co/kVRfQ6AmUg
https://t.co/XvFflZOgzr 経口VCM ローディング検討?なのかなー
@gamecox2001 @idchat1 Check out fecal conc here: http://t.co/ItRVum9wfL #IDChat