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Chinese herbal medicine for impaired glucose tolerance: a randomized placebo controlled trial

Overview of attention for article published in BMC Complementary and Alternative Medicine, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

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8 tweeters
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1 Facebook page
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1 Redditor

Citations

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14 Dimensions

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50 Mendeley
Title
Chinese herbal medicine for impaired glucose tolerance: a randomized placebo controlled trial
Published in
BMC Complementary and Alternative Medicine, May 2013
DOI 10.1186/1472-6882-13-104
Pubmed ID
Authors

Suzanne J Grant, Dennis Hsu-Tung Chang, Jianxun Liu, Vincent Wong, Hosen Kiat, Alan Bensoussan

Abstract

BACKGROUND: Diabetes remains a major health problem worldwide. Low-risk low-cost alternatives to pharmaceutical interventions are needed where lifestyle modifications have failed. We conducted a double-blind randomised placebo controlled trial to investigate the efficacy of a Chinese herbal formula, Jiangtang Xiaozhi, in treating impaired glucose control and insulin resistance in persons with prediabetes and controlled diabetes. METHODS: Seventy-one patients with prediabetes or 'controlled' diabetes were randomised to receive 3 capsules of Jiangtang Xiaozhi (n = 39) or placebo (n = 32) three times daily for 16 weeks with a follow up eight weeks later (week 24). The primary outcome was change in glycaemic control as evidenced by fasting blood glucose (FBG), post-prandial plasma glucose and glycosylated haemoglobin (HbA1c). Other measures included change in fasting insulin, insulin resistance and sensitivity, lipids, C-reactive protein (CRP), body mass index (BMI), waist girth, blood pressure (BP), health related quality of life (HRQoL) and safety. Analysis of covariance (ANCOVA) was used to model outcomes at 16 weeks, by treatment group corrected for baseline level of the outcome variable. RESULTS: In patients receiving Jiangtang Xiaozhi, FBG was not significantly different (p =0.73) compared to placebo after 16 weeks of treatment (6.3 +/- 1.1 mmol/L vs 6.7 +/- 1.3 mmol/L). There was a significant difference (p = 0.04) in the mean levels of fasting insulin between the treatment group (11.6 +/- 5.5 mmol/L) and the placebo group (22.1 +/- 25.9 mmol/L). Insulin resistance slightly decreased in the treatment group (1.58 +/- 0.74) compared to that of the placebo group (2.43 +/- 1.59) but this change did not reach statistical significance (p = 0.06). Patients taking Jiangtang Xiaozhi had a significant improvement in high-density lipoprotein (HDL) level compared to the placebo group at week 16 (p = 0.03). Mean levels of cholesterol, triglycerides, BMI, waist-girth, HRQoL, BP, CRP and insulin sensitivity were not significantly different between the two groups. The herbal medicine was well tolerated. CONCLUSIONS: In the current study, the 16 week Jiangtang Xiaozhi treatment did not lower fasting blood glucose, but it improved serum insulin and HDL cholesterol in a Western population with prediabetes or controlled diabetes. Our trial may have been underpowered. Dosage needs to be considered before commencing a longer adequately powered trial.Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12612000128897; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=362005.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 24%
Student > Ph. D. Student 9 18%
Other 7 14%
Student > Postgraduate 5 10%
Student > Bachelor 4 8%
Other 13 26%
Readers by discipline Count As %
Medicine and Dentistry 24 48%
Agricultural and Biological Sciences 6 12%
Nursing and Health Professions 3 6%
Mathematics 3 6%
Unspecified 3 6%
Other 11 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2013.
All research outputs
#2,150,011
of 12,373,386 outputs
Outputs from BMC Complementary and Alternative Medicine
#507
of 2,512 outputs
Outputs of similar age
#26,791
of 145,347 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#10
of 11 outputs
Altmetric has tracked 12,373,386 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,512 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 145,347 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.