| Title |
Type 1 diabetes and cardiovascular disease
|
|---|---|
| Published in |
Cardiovascular Diabetology, January 2013
|
| DOI | 10.1186/1475-2840-12-156 |
| Pubmed ID | |
| Authors |
Oliver Schnell, Francesco Cappuccio, Stefano Genovese, Eberhard Standl, Paul Valensi, Antonio Ceriello |
| Abstract |
The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor of both micro- and macrovascular complications. In Type 1 diabetes, the presence of coronary calcifications is also related to coronary artery disease. Cardiac autonomic neuropathy, which significantly impairs myocardial function and blood flow, also enhances cardiac abnormalities. Also hypoglycemic episodes are considered to adversely influence cardiac performance. Intensive insulin therapy has been demonstrated to reduce the occurrence and progression of both micro- and macrovascular complications. This has been evidenced by the Diabetes Control and Complications Trial (DCCT) / Epidemiology of Diabetes Interventions and Complications (EDIC) study. The concept of a metabolic memory emerged based on the results of the study, which established that intensified insulin therapy is the standard of treatment of Type 1 diabetes. Future therapies may also include glucagon-like peptide (GLP)-based treatment therapies. Pilot studies with GLP-1-analogues have been shown to reduce insulin requirements. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 29% |
| United States | 3 | 18% |
| Ireland | 1 | 6% |
| Pakistan | 1 | 6% |
| Unknown | 7 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 53% |
| Practitioners (doctors, other healthcare professionals) | 5 | 29% |
| Scientists | 3 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | <1% |
| Brazil | 1 | <1% |
| South Africa | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 197 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 14% |
| Student > Bachelor | 27 | 13% |
| Student > Ph. D. Student | 23 | 11% |
| Student > Doctoral Student | 18 | 9% |
| Student > Postgraduate | 17 | 8% |
| Other | 44 | 22% |
| Unknown | 46 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 81 | 40% |
| Biochemistry, Genetics and Molecular Biology | 20 | 10% |
| Agricultural and Biological Sciences | 13 | 6% |
| Nursing and Health Professions | 13 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
| Other | 22 | 11% |
| Unknown | 46 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2021.
All research outputs
#2,848,029
of 22,727,570 outputs
Outputs from Cardiovascular Diabetology
#183
of 1,367 outputs
Outputs of similar age
#30,412
of 280,760 outputs
Outputs of similar age from Cardiovascular Diabetology
#5
of 66 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,367 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,760 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.