Report for: Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Title	Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
Published in	Journal of Neuroinflammation, January 2014
DOI	10.1186/1742-2094-11-98
Pubmed ID	24889886
Authors	Jonathan D Cherry, John A Olschowka, M O’Banion
Abstract	The concept of multiple macrophage activation states is not new. However, extending this idea to resident tissue macrophages, like microglia, has gained increased interest in recent years. Unfortunately, the research on peripheral macrophage polarization does not necessarily translate accurately to their central nervous system (CNS) counterparts. Even though pro- and anti-inflammatory cytokines can polarize microglia to distinct activation states, the specific functions of these states is still an area of intense debate. This review examines the multiple possible activation states microglia can be polarized to. This is followed by a detailed description of microglial polarization and the functional relevance of this process in both acute and chronic CNS disease models described in the literature. Particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.

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Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United States	2	33%
Venezuela, Bolivarian Republic of	1	17%
Australia	1	17%
Unknown	2	33%

Demographic breakdown

Type	Count	As %
Members of the public	3	50%
Science communicators (journalists, bloggers, editors)	1	17%
Scientists	1	17%
Practitioners (doctors, other healthcare professionals)	1	17%

Mendeley readers

The data shown below were compiled from readership statistics for 1,134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	8	<1%
United Kingdom	3	<1%
Spain	2	<1%
France	2	<1%
South Africa	1	<1%
Italy	1	<1%
Indonesia	1	<1%
Canada	1	<1%
Mexico	1	<1%
Other	3	<1%
Unknown	1111	98%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	266	23%
Student > Bachelor	204	18%
Student > Master	189	17%
Researcher	146	13%
Student > Doctoral Student	79	7%
Other	133	12%
Unknown	117	10%

Readers by discipline	Count	As %
Neuroscience	299	26%
Agricultural and Biological Sciences	243	21%
Biochemistry, Genetics and Molecular Biology	144	13%
Medicine and Dentistry	134	12%
Pharmacology, Toxicology and Pharmaceutical Science	41	4%
Other	115	10%
Unknown	158	14%

Attention Score in Context

This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2020.

All research outputs

#339,814

of 16,360,960 outputs

Outputs from Journal of Neuroinflammation

#22

of 2,051 outputs

Outputs of similar age

#4,341

of 192,840 outputs

Outputs of similar age from Journal of Neuroinflammation

of 16 outputs

Altmetric has tracked 16,360,960 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 2,051 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 98% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,840 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.

We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

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Geographical breakdown

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Attention Score in Context