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Effect of crude leaf extract of Osyris quadripartita on Plasmodium berghei in Swiss albino mice

Overview of attention for article published in BMC Complementary and Alternative Medicine, June 2015
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Title
Effect of crude leaf extract of Osyris quadripartita on Plasmodium berghei in Swiss albino mice
Published in
BMC Complementary and Alternative Medicine, June 2015
DOI 10.1186/s12906-015-0715-3
Pubmed ID
Authors

Senait Girma, Mirutse Giday, Berhanu Erko, Hassen Mamo

Abstract

Continuous emergence of multi-drug-resistant malaria parasites and their rapid spread across the globe warrant urgent search for new anti-malarial chemotherapeutics. Traditional medicinal plants have been the main sources for screening active phytochemicals against malaria. Accordingly, this study was aimed at evaluating the anti-malarial activity of Osyris quadripartita Salzm. Ex Decne., a plant which is used for traditional malaria treatment by local people in different parts of Ethiopia. Aqueous, chloroform and methanol crude leaf extracts of the plant have been prepared and tested for acute toxicity and anti-malarial efficacy in Plasmodium berghei (ANKA strain)-infected Swiss albino mice. At three oral doses of 200, 400 and 600 mg/kg the plant material was safe, chemosuppressive and thus prevented body weight loss, hematological abnormalities and increased mice mean survival time compared to the negative control. The most efficacious extract was that of chloroform which prolonged mean mouse survival past day 11 of infection with all the mice in this group having the highest parasitemia suppression rate (41.3 %, at 600 mg/kg) although parasite clearance was not achieved compared to the standard drug (chloroquine) against the parasite. The finding supports the traditional use of the plant for the treatment of malaria. However, further confirmatory studies followed by isolation and characterization of the active anti-malarial compound (s) of the plant that is/are responsible for the observed parasite suppression is needed before it is recommended for malaria drug search and discovery.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 1 3%
Malaysia 1 3%
United Kingdom 1 3%
Unknown 28 90%

Demographic breakdown

Readers by professional status Count As %
Unspecified 8 26%
Student > Master 7 23%
Student > Ph. D. Student 7 23%
Student > Bachelor 3 10%
Student > Doctoral Student 2 6%
Other 4 13%
Readers by discipline Count As %
Unspecified 10 32%
Medicine and Dentistry 5 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Chemistry 3 10%
Immunology and Microbiology 3 10%
Other 7 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2015.
All research outputs
#4,356,934
of 5,234,334 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,380
of 1,580 outputs
Outputs of similar age
#149,421
of 184,395 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#68
of 79 outputs
Altmetric has tracked 5,234,334 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,580 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,395 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.