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Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

Overview of attention for article published in BMC Cancer, October 2011
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Mentioned by

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1 tweeter

Citations

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71 Dimensions

Readers on

mendeley
55 Mendeley
Title
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
Published in
BMC Cancer, October 2011
DOI 10.1186/1471-2407-11-468
Pubmed ID
Authors

Jeffery D Eskew, Takrima Sadikot, Pedro Morales, Alicia Duren, Irene Dunwiddie, Megan Swink, Xiaoying Zhang, Stacey Hembruff, Alison Donnelly, Roger A Rajewski, Brian SJ Blagg, Jacob R Manjarrez, Robert L Matts, Jeffrey M Holzbeierlein, George A Vielhauer

Abstract

The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity and resistance resulting from induction of the heat shock response (HSR) has led to both scheduling and administration concerns. Therefore, Hsp90 inhibitors that do not induce the heat shock response represent a promising new direction for the treatment of prostate cancer. Herein, the development of a C-terminal Hsp90 inhibitor, KU174, is described, which demonstrates anti-cancer activity in prostate cancer cells in the absence of a HSR and describe a novel approach to characterize Hsp90 inhibition in cancer cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 35%
Researcher 11 20%
Student > Bachelor 8 15%
Student > Master 6 11%
Other 2 4%
Other 6 11%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 31%
Biochemistry, Genetics and Molecular Biology 11 20%
Chemistry 11 20%
Medicine and Dentistry 4 7%
Engineering 2 4%
Other 4 7%
Unknown 6 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2011.
All research outputs
#7,762,237
of 12,372,945 outputs
Outputs from BMC Cancer
#2,221
of 4,558 outputs
Outputs of similar age
#61,560
of 104,513 outputs
Outputs of similar age from BMC Cancer
#126
of 271 outputs
Altmetric has tracked 12,372,945 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,558 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,513 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 271 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.