Title |
Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene
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Published in |
BMC Cancer, October 2010
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DOI | 10.1186/1471-2407-10-540 |
Pubmed ID | |
Authors |
Lisa Becks, Misty Prince, Hannah Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki Yamamoto, Michael Mathis, Elysse Orchard, Runhua Shi, Jerry McLarty, Kevin Pruitt, Songlin Zhang, Heather E Kleiner-Hancock |
Abstract |
Activation of nuclear factor erythroid 2-related factor (Nrf2), which belongs to the basic leucine zipper transcription factor family, is a strategy for cancer chemopreventive phytochemicals. It is an important regulator of genes induced by oxidative stress, such as glutathione S-transferases, heme oxygenase-1 and peroxiredoxin 1, by activating the antioxidant response element (ARE). We hypothesized that (1) the citrus coumarin auraptene may suppress premalignant mammary lesions via activation of Nrf2/ARE, and (2) that Nrf2 knockout (KO) mice would be more susceptible to mammary carcinogenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 19% |
Student > Doctoral Student | 8 | 14% |
Student > Ph. D. Student | 6 | 10% |
Student > Master | 6 | 10% |
Student > Bachelor | 5 | 8% |
Other | 13 | 22% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 25% |
Agricultural and Biological Sciences | 11 | 19% |
Medicine and Dentistry | 10 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Nursing and Health Professions | 2 | 3% |
Other | 4 | 7% |
Unknown | 12 | 20% |