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Statistical challenges in the development and evaluation of marker-based clinical tests

Overview of attention for article published in BMC Medicine, May 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

1 blog
1 policy source
5 X users


13 Dimensions

Readers on

37 Mendeley
Statistical challenges in the development and evaluation of marker-based clinical tests
Published in
BMC Medicine, May 2012
DOI 10.1186/1741-7015-10-52
Pubmed ID

Lisa M McShane


Exciting new technologies for assessing markers in human specimens are now available to evaluate unprecedented types and numbers of variations in DNA, RNA, proteins, or biological structures such as chromosomes. These markers, whether viewed individually, or collectively as a 'signature', have the potential to be useful for disease risk assessment, screening, early detection, prognosis, therapy selection, and monitoring for therapy effectiveness or disease recurrence. Successful translation from basic research findings to clinically useful test requires basic, translational, and regulatory sciences and a collaborative effort among individuals with varied types of expertise including laboratory scientists, technology developers, clinicians, statisticians, and bioinformaticians. The focus of this commentary is the many statistical challenges in translational marker research, specifically in the development and validation of marker-based tests that have clinical utility for therapeutic decision-making.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 2 5%
Australia 1 3%
Lithuania 1 3%
United Kingdom 1 3%
United States 1 3%
Unknown 31 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 27%
Student > Master 7 19%
Other 4 11%
Professor 3 8%
Student > Ph. D. Student 3 8%
Other 6 16%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 24%
Medicine and Dentistry 8 22%
Biochemistry, Genetics and Molecular Biology 6 16%
Mathematics 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 3 8%
Unknown 6 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2015.
All research outputs
of 22,665,794 outputs
Outputs from BMC Medicine
of 3,397 outputs
Outputs of similar age
of 165,058 outputs
Outputs of similar age from BMC Medicine
of 35 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,397 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,058 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.