Title |
Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population
|
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Published in |
BMC Medicine, June 2012
|
DOI | 10.1186/1741-7015-10-61 |
Pubmed ID | |
Authors |
James K Ellis, Toby J Athersuch, Laura DK Thomas, Friederike Teichert, Miriam Pérez-Trujillo, Claus Svendsen, David J Spurgeon, Rajinder Singh, Lars Järup, Jacob G Bundy, Hector C Keun |
Abstract |
The 'exposome' represents the accumulation of all environmental exposures across a lifetime. Top-down strategies are required to assess something this comprehensive, and could transform our understanding of how environmental factors affect human health. Metabolic profiling (metabonomics/metabolomics) defines an individual's metabolic phenotype, which is influenced by genotype, diet, lifestyle, health and xenobiotic exposure, and could also reveal intermediate biomarkers for disease risk that reflect adaptive response to exposure. We investigated changes in metabolism in volunteers living near a point source of environmental pollution: a closed zinc smelter with associated elevated levels of environmental cadmium. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 13% |
United States | 2 | 13% |
United Kingdom | 1 | 6% |
Japan | 1 | 6% |
Singapore | 1 | 6% |
Unknown | 9 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 50% |
Scientists | 6 | 38% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
United Kingdom | 1 | <1% |
Peru | 1 | <1% |
Belgium | 1 | <1% |
Korea, Republic of | 1 | <1% |
Unknown | 135 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 38 | 27% |
Student > Ph. D. Student | 33 | 24% |
Student > Bachelor | 12 | 9% |
Student > Master | 7 | 5% |
Student > Doctoral Student | 7 | 5% |
Other | 21 | 15% |
Unknown | 22 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Environmental Science | 22 | 16% |
Agricultural and Biological Sciences | 19 | 14% |
Medicine and Dentistry | 18 | 13% |
Chemistry | 15 | 11% |
Biochemistry, Genetics and Molecular Biology | 14 | 10% |
Other | 23 | 16% |
Unknown | 29 | 21% |