Title |
Hornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer
|
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Published in |
BMC Cancer, June 2012
|
DOI | 10.1186/1471-2407-12-266 |
Pubmed ID | |
Authors |
Jodie M Fleming, Erika Ginsburg, Shannon D Oliver, Paul Goldsmith, Barbara K Vonderhaar |
Abstract |
Recent evidence suggests an emerging role for S100 protein in breast cancer and tumor progression. These ubiquitous proteins are involved in numerous normal and pathological cell functions including inflammatory and immune responses, Ca(2+) homeostasis, the dynamics of cytoskeleton constituents, as well as cell proliferation, differentiation, and death. Our previous proteomic analysis demonstrated the presence of hornerin, an S100 family member, in breast tissue and extracellular matrix. Hornerin has been reported in healthy skin as well as psoriatic and regenerating skin after wound healing, suggesting a role in inflammatory/immune response or proliferation. In the present study we investigated hornerin's potential role in normal breast cells and breast cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 32% |
Student > Master | 9 | 18% |
Researcher | 7 | 14% |
Professor > Associate Professor | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 5 | 10% |
Unknown | 6 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 30% |
Medicine and Dentistry | 14 | 28% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Engineering | 4 | 8% |
Immunology and Microbiology | 1 | 2% |
Other | 2 | 4% |
Unknown | 7 | 14% |