Title |
Dysexecutive syndrome in amnesic mild cognitive impairment: a multicenter study
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Published in |
BMC Neurology, June 2016
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DOI | 10.1186/s12883-016-0607-2 |
Pubmed ID | |
Authors |
E. Blanco Martín, I. Ugarriza Serrano, X. Elcoroaristizabal Martín, L. Galdos Alcelay, A. Molano Salazar, R. Bereincua Gandarias, S. Inglés Borda, J. M. Uterga Valiente, M. B. Indakoetxea Juanbeltz, J. Moraza Lopez, M. Barandiarán Amillano, M. Fernández-Martínez |
Abstract |
Executive functions (EF) in Alzheimer's disease (AD), classically related to the prefrontal cortex, have been forgotten in mild stages, given more importance to temporal lobe associated disorders, such as memory. The study of disexecutive syndrome (DS) has been relegated to advanced stages of the disease. Our goal is to demonstrate that EF are already present in amnesic mild cognitive impairment (aMCI). Furthermore, we are interested in knowing whether poor scores in EF tests are related to the progression to AD or another kind of dementia. We studied patients with aMCI (n = 81) and healthy controls (n = 142) from neurological departments of several centers of Basque Country with a cross-sectional design. Patients underwent a complete neuropsychological evaluation, neuroimaging testing APOE genotype and 3 year of prospective follow-up. In the first visit, patients with aMCI showed more alterations in tests that evaluate EF such as Stroop, trail-making and categorical verbal fluency. More alterations were also found in NPI scale (P <0.05). Stroop and Trail-Making test were not associated with the future development of AD, but fluency (p = 0.01) and apathy (p = 0.031) did. No patient developed a different kind of dementia different from AD. DS is a broad concept not confined to frontal lobes, and can be found in early stages of aMCI. DS impacts negatively on patient autonomy and may have prognostic value. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 85 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 16% |
Student > Ph. D. Student | 13 | 15% |
Student > Bachelor | 11 | 13% |
Researcher | 9 | 10% |
Student > Doctoral Student | 7 | 8% |
Other | 11 | 13% |
Unknown | 21 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 28 | 33% |
Neuroscience | 9 | 10% |
Nursing and Health Professions | 7 | 8% |
Medicine and Dentistry | 7 | 8% |
Environmental Science | 2 | 2% |
Other | 8 | 9% |
Unknown | 25 | 29% |