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Dealing with heterogeneity of treatment effects: is the literature up to the challenge?

Overview of attention for article published in Trials, June 2009
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Dealing with heterogeneity of treatment effects: is the literature up to the challenge?
Published in
Trials, June 2009
DOI 10.1186/1745-6215-10-43
Pubmed ID

Nicole B Gabler, Naihua Duan, Diana Liao, Joann G Elmore, Theodore G Ganiats, Richard L Kravitz


Some patients will experience more or less benefit from treatment than the averages reported from clinical trials; such variation in therapeutic outcome is termed heterogeneity of treatment effects (HTE). Identifying HTE is necessary to individualize treatment. The degree to which heterogeneity is sought and analyzed correctly in the general medical literature is unknown. We undertook this literature sample to track the use of HTE analyses over time, examine the appropriateness of the statistical methods used, and explore the predictors of such analyses.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 6%
United Kingdom 3 3%
France 1 1%
Unknown 85 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 20%
Student > Ph. D. Student 13 14%
Student > Master 11 12%
Other 9 9%
Professor 7 7%
Other 22 23%
Unknown 14 15%
Readers by discipline Count As %
Medicine and Dentistry 34 36%
Social Sciences 7 7%
Computer Science 6 6%
Economics, Econometrics and Finance 5 5%
Nursing and Health Professions 4 4%
Other 20 21%
Unknown 19 20%