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Does the central dogma still stand?

Overview of attention for article published in Biology Direct, August 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#30 of 537)
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

1 blog
18 X users
1 Facebook page
3 Wikipedia pages


58 Dimensions

Readers on

339 Mendeley
2 CiteULike
Does the central dogma still stand?
Published in
Biology Direct, August 2012
DOI 10.1186/1745-6150-7-27
Pubmed ID

Eugene V Koonin


Prions are agents of analog, protein conformation-based inheritance that can confer beneficial phenotypes to cells, especially under stress. Combined with genetic variation, prion-mediated inheritance can be channeled into prion-independent genomic inheritance. Latest screening shows that prions are common, at least in fungi. Thus, there is non-negligible flow of information from proteins to the genome in modern cells, in a direct violation of the Central Dogma of molecular biology. The prion-mediated heredity that violates the Central Dogma appears to be a specific, most radical manifestation of the widespread assimilation of protein (epigenetic) variation into genetic variation. The epigenetic variation precedes and facilitates genetic adaptation through a general 'look-ahead effect' of phenotypic mutations. This direction of the information flow is likely to be one of the important routes of environment-genome interaction and could substantially contribute to the evolution of complex adaptive traits.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 339 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
Spain 4 1%
Germany 2 <1%
Brazil 2 <1%
United Kingdom 2 <1%
Canada 2 <1%
Netherlands 1 <1%
Peru 1 <1%
Norway 1 <1%
Other 4 1%
Unknown 315 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 21%
Student > Bachelor 51 15%
Researcher 48 14%
Student > Master 44 13%
Professor 14 4%
Other 44 13%
Unknown 66 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 115 34%
Biochemistry, Genetics and Molecular Biology 67 20%
Medicine and Dentistry 18 5%
Immunology and Microbiology 11 3%
Engineering 9 3%
Other 41 12%
Unknown 78 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2023.
All research outputs
of 25,374,647 outputs
Outputs from Biology Direct
of 537 outputs
Outputs of similar age
of 186,645 outputs
Outputs of similar age from Biology Direct
of 10 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,645 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.